Cardiological therapy is refined day by day on the basis of clinical trials and meta-analyses, the results of which, insufficiently known or applied, have demonstrated and justified with an almost absolute strength of evidence the value of a given molecule depending on the patient’s clinical state. The proposed treatment guidelines are directly derived from the results of more than four hundred large-scale clinical trials and one hundred and a half studies and meta-analyses, amplified and strengthened by the main guidelines of scientific societies, usually American or European. These treatment guidelines provide the prescriber with a scientific and practical guide to the procedures and rules that now govern modern cardiological therapy in line with the most recent scientific data.